Denver will end many of its public health restrictions this weekend, a spokeswoman said Thursday, a move that will represent the most significant dismantling of COVID-19 measures yet.

Several other metro-area counties will all move to “Level Clear” Sunday, according to the public health orders that will expire after Saturday. Denver officials have long said they’ll move in step with the county’s neighbors, and spokeswoman Clarissa Boggs-Blake said in an email that while details are being finalized, “we are aligning with standards for Level Clear.”

Under this new category, capacity restrictions and mitigation efforts will be eliminated. State-level orders, like the mask mandate, will remain in place, and the orders in other metro counties give businesses the option to implement their own restrictions.

While the other counties will enter a 90-day observation time frame, BoggsBlake said that Denver will “be continuously monitoring metrics, not just for the 90-day timeframe specific in level clear guidance.” Bob McDonald, the executive director of the Denver Department of Public Health and Environment, previously said that Denver will remain flexible and ready to re-implement public health restrictions if cases rise.

While Denver’s order has not been released, the other metro counties’ orders indicate that restrictions will be reimplemented to varying degrees based on hospitalization rates.

Denver’s imminent move is the latest sign that the behavioral changes that have come to define the pandemic are on the way out.

On Thursday, the Centers for Disease Control and Prevention announced that fully vaccinated people largely don’t need to wear masks indoors anymore. Shortly after, Colorado health officials said they would review the guidance, and a spokeswoman for Gov. Jared Polis said the state would change its mask mandate “shortly” to align with the new federal recommendations.

The statewide mask mandate had already been significantly pared back. Under the current order, masks aren’t necessary indoors if there are fewer than 10 people inside or if 80% of occupants have been vaccinated. Staff at restaurants don’t need to wear masks if 85% of them have been inoculated.

Public health measures across Colorado have been slowly unwound over the past several weeks. In mid-April, the state Department of Public Health and Environment ceded much of the authority to institute restrictions to counties. Many promptly did away with most restrictions, and the metro area almost uniformly loosened many restrictions but kept minor limitations in place.

When counties took over in mid-April, the constellation of health departments that cover the metro area nearly all said they would institute similar orders to maintain consistency. Douglas County was an outlier and moved to unwind restrictions even further. At the time, officials in the metro area indicated that, should cases and hospitalizations not spiral, many remaining mitigation measures would end in mid-May.

That’s set to happen this weekend. Like the state as a whole, Denver had a fourth wave that emerged in April. But it has largely abated, as it has statewide.

As of Thursday night, the average number of new daily COVID cases in Denver is as low as it’s been since early October. Though there are more people hospitalized now in Denver than there have been in weeks, the average number of new admissions has dropped back to pre-spike levels.